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::General Information
ID U0015
Creation Date 08 May 2000
Updating Date 08 May 2000
Standard Name Internal Ribosome Entry Site (IRES)
UTRSite Pattern 
r1={au,ua,cg,gc,gu,ug}
p1=5...6 0...6 p2=5...6 p3=0...2
p4=5...8 p5=3...8
r1~p4[1,0,0] p6=5...8 p7=3...5
r1~p6[1,0,0] p8=0...5
r1~p2[1,0,0] 0...6
r1~p1[1,0,0] 2...5 p9=5...6 p10=3...8
r1~p9[1,0,0] 3...10 ATG 97...97 $
Random Expectation 0.0068809300 hits/kb
::Taxonomy
UTR Region 5'
Taxon Range Eukaryota
::Description
Description Internal mRNA ribosome binding is a mechanism of translation initiation alternative to the conventional 5'-cap dependendent ribosome scanning mechanism. The internal initiation mechanism, first observed in picornavirus, is also found in some cellular mRNAs, such as human immunoglobulin heavy chain binding protein (BiP) mRNA, Antennapedia mRNA of drosophila and FGF-2 mRNA. This mechanism may be advantageous for specific translation of mRNAs during cell cycle when underphosphorilat......
::Features
Feature Key IRES
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
5' UTR in Rattus norvegicus fibroblast growth factor 2 (Fgf2), mRNA. Rattus norvegicus UTRef: 5RNOR017863 [U1]
Transcript(s)
Description Species Link Ref.
Rattus norvegicus fibroblast growth factor 2 (Fgf2), mRNA. Rattus norvegicus RefSeq: NM_019305 [T1]
Gene(s)
Description Species Link Ref.
Fgf2 fibroblast growth factor 2. Rattus norvegicus EntrezGene: 54250 [G1]
::References
ID [1] [U1] [T1] [G1]
Authors Le, S.Y., and Maizel,J.V.,Jr.
Title A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs
Citation Nucleic Acids Res.25,362-69
Year 1997