Signal Manager :: View

::General Information
ID	U0024
Creation Date	22 November 2002
Updating Date	22 November 2002
Standard Name	Brd-Box (Brd)
UTRSite Pattern	AGCTTTA
Random Expectation	0.0796282000 hits/kb
::Taxonomy
UTR Region	3'
Taxon Range	Metazoa
::Description
Description	Many Notch pathway target genes in Drosophila, including most members of the basic helix-loop-helix repressor family and the Bearded family, contain a series of conserved sequence motifs in their 3' UTRs, including the Brd box, the K box, and the GY box. The Brd box (AGCTTTA) is present in one or more copies in many of these 3'UTRs and mediates negative post-transcriptional regulation by affecting transcript stability and translational efficiency. Regulation by the Brd box is spati......
::Features
Feature Key	BRD-BOX
::Transcript(s) / Gene(s)
UTR(s)	Description Species Link Ref. 3' UTR in Drosophila melanogaster bearded (Brd), mRNA. Drosophila melanogaster UTRef: 3DMER010425 [U1]
Transcript(s)	Description Species Link Ref. Drosophila melanogaster bearded (Brd), mRNA. Drosophila melanogaster RefSeq: NM_057541 [T1]
Gene(s)	Description Species Link Ref. Brd Bearded. Drosophila melanogaster EntrezGene: 39620 [G1]
::References
ID	[1] [U1] [T1] [G1]
Authors	Lai et al.
Title	The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts
Citation	Development 125:4077-88
Year	1998
ID	[2]
Authors	Lai E.C.
Title	Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation
Citation	Nature Genetics. 30:363-4
Year	2002